NMDA receptor hypofunction on GABAergic interneurons results in input-specific Excitatory/Inhibitory imbalance in pyramidal neurons of medial prefrontal cortex.
Excitation/inhibition (E/I) balance in cortical circuits is typically treated as a global neuronal property, yet pyramidal neurons integrate synaptic inputs from anatomically distinct afferent pathways whose regulation may not be uniform. Using a mouse model with early postnatal NMDA receptor (NMDAR) ablation from corticolimbic GABAergic interneurons associated E/I dysfunction, we tested whether…
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