Long-term risk for incident psoriasis elevated with irritable bowel syndrome
Patients with irritable bowel syndrome (IBS) have an increased risk of incident psoriasis, according to a study published online Aug. 7 in the Journal of Global Health.
A study published in the Journal of Global Health found that patients with irritable bowel syndrome (IBS) have a higher long-term risk of developing incident psoriasis, compared to those without IBS. Researchers analyzed data from 437,170 participants in the U.K. Biobank, who were initially free of psoriasis. Over a median follow-up period of 14.4 years, 5.0% of participants developed IBS, while 1.0% experienced incident psoriasis.
Patients with IBS had a 35% increased risk of developing psoriasis compared to patients without IBS (hazard ratio, 1.35). The psoriasis risk associated with IBS remained significant in various subgroup analyses based on age, sex, socioeconomic status, smoking habits, nonsteroidal anti-inflammatory drug use, inflammation markers, and genetic predisposition.
The findings suggest that IBS patients should be monitored for the early signs of psoriasis and that there may be shared underlying mechanisms between the two conditions. However, further research in diverse populations is needed to confirm these results and understand the biological pathways involved.
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