Compact Oligomerized-Motif Promoters for Adjustable Control of Transcription (COMPACT) for Robust, Tunable and Bidirectional Gene Expression in Mammalian Cells
Native promoters derived from mammalian and viral genomes are commonly used to drive transgene expression. However, their size, sequence, and structural complexity can impede predictable tuning of promoter activity, increase susceptibility to silencing, consume valuable space in viral vectors, and increase the risk of homologous recombination with host genomes. Here, we systematically compared…
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