An intact primordial interferon antiviral signalling network in amphioxus illuminates the basal chordate origin of vertebrate IFN immunity
The evolutionary origin of the complete interferon (IFN) antiviral signalling cascade across chordates has long remained elusive, as fully functional IFN machinery had not been biochemically reconstituted in basal cephalochordates. Here we combine phylogenetics, AlphaFold3 structural prediction, multi-omic profiling and a full panel of in vitro and in vivo functional assays to characterize an…
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