A Dominant-Negative HIF-1 Isoform Protects Neuronal Development by Buffering the Response to Hypoxia in C. elegans
Animal cells respond to hypoxic stress through cell-autonomous stabilization of HIF-1, a conserved transcription factor that mediates adaptation to low-oxygen environments. Although HIF-1 is essential for viability under hypoxia, its persistent activation during development causes miswiring defects in the nervous system, raising the question of how developing neurons balance the pro-survival…
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