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Autoantibodies neutralizing type I interferons underlie a third of cases of Chikungunya virus encephalitis or myelitis

Proceedings of the National Academy of Sciences, Volume 123, Issue 34, August 2026. SignificanceChikungunya virus (CHIKV) infection results in life-threatening central nervous system (CNS) complications in rare cases. We found that autoantibodies neutralizing type I interferons underlie severe CNS CHIKV infection in 35% of the patients ...

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