Focused framework sampling recovers binding-positive humanized anti-amyloid-β antibodies in a single sorting round
Therapeutic antibody development requires workflows that integrate antigen-reactive clone discovery with efficient humanization and early developability assessment. Here, we combined immune yeast fragment antigen-binding (Fab) display with single-round focused humanization and applied the workflow to antibodies against amyloid-beta (Abeta)-derived preparations. Immunization with Abeta1-42…
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