Boy's stem cell transplant gives hope to UAE family after loss of baby girl

A Pakistani family from the UAE has been given hope for their younger son's life after their six-month-old daughter died from pneumonia in 2023. Shayan Arif, 35, and Noor ul Ain Khan, 29, lost their baby Hamda to a severe infection after she endured 22 days in hospital. Though no genetic condition was diagnosed at the time, Hamdan began suffering from a prolonged fever at five months old.

After two years of investigation, doctors diagnosed him with a rare RAG1-related immunodeficiency and Omenn syndrome, both life-threatening genetic diseases. The family moved to the UAE when Shayan was transferred for work, and Hamdan was born in Sharjah in April 2025. At around five months old, Hamdan developed a rash, infection, and fever.

Doctors initially treated it as a routine infection, but after 20 days, Hamdan suffered from a fever for over a month. Hospitalized, Hamdan received steroids and was investigated for an abnormal immune system. Genetic testing confirmed his condition and hinted at his sister's possible diagnosis, as both parents are carriers of the RAG1 mutation.

A stem cell transplant was recommended, and Hamdan received a father's half-matched donor. His immune system is severely compromised, making him susceptible to infections. The family's experience highlights the importance of early genetic testing and the potential life-saving impact of stem cell transplants.