A periplasmic regulator establishes adaptive impermeability to control carbapenem entry
Outer-membrane permeability is a major determinant of antibiotic susceptibility in Gram-negative bacteria and is generally thought to be controlled through transcriptional regulation of porin expression. Here we identify the small periplasmic protein PtrA as a regulator of OprD-dependent carbapenem permeability in Pseudomonas aeruginosa. PtrA promotes imipenem resistance without altering OprD…
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