A new way to beat jet lag? Engineered cells speed circadian adjustment

A study published in Advanced Science has revealed a promising new approach to beat jet lag by using engineered cells to speed up circadian adjustment. The therapy consists of human retinal pigment epithelial cells that are engineered to continuously produce leptin, a metabolic hormone that regulates appetite and metabolism.

In a series of experiments with rodents and nonhuman primates, the encapsulated leptin-producing cells were injected subcutaneously and temporarily elevated circulating leptin levels. This accelerated the body's adaptation to shifts in the light-dark cycle, mimicking jet lag and shift work. Animals treated with the therapy adjusted significantly faster than control animals, adapting 50% quicker in mice for a four-hour delay and reducing a six-hour shift by approximately one day in macaques.

The therapy provided a practical and reversible solution to circadian disruption, with no long-term adverse effects observed in nonhuman primates. Sleep architecture remained unaffected, indicating that the treatment did not compromise sleep quality. The encapsulated cells remained active for several days, offering a temporary and self-resolving intervention.

The researchers believe this metabolic signaling approach could revolutionize how we address circadian rhythm issues, particularly for those facing frequent disruptions such as shift workers, military personnel, and frequent travelers. By harnessing the power of engineered cells, this innovative therapy offers a new pathway to optimize circadian alignment, improving overall health and well-being.