TriTower-m6Am: a triple-tower heterogeneous deep learning architecture integrating semantic, sequential, and structural information for mRNA N6,2'-O-dimethyladenosine site prediction
Background: N6,2'-O-dimethyladenosine (m6Am) is a cap-proximal mRNA modification deposited by PCIF1 at the first transcribed nucleotide of eukaryotic mRNAs. Knowing where m6Am sites sit across the transcriptome would help explain how cells tune mRNA stability and translation, but current computational predictors typically depend on a single sequence representation and do not jointly model the…
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