Leveraging Targeted Gene Sets and Neural Networks for Zebrafish Transcriptome Extrapolation in High-Throughput Toxicogenomics
Background: Zebrafish (Danio rerio) are a powerful vertebrate model for developmental toxicology and chemical safety assessment, yet large-scale transcriptomics in zebrafish remains limited by cost and data heterogeneity. Targeted transcriptomics offers a cost-effective alternative, but gene extrapolation methods tailored to zebrafish have not been systematically developed or evaluated.…
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