A surprising triple treatment completely clears hiv in newborn primates
Researchers have found a striking new way to potentially eliminate HIV soon after infection using a one-time combination of three therapies. In newborn nonhuman primates treated within three days of exposure, the regimen—standard antiretroviral drugs, broadly neutralizing antibodies, and the experimental antibody leronlimab—completely cleared the virus, even though none of the treatments could do…
Newborn primates treated with a combination of three therapies show potential for permanently clearing HIV infection, according to a groundbreaking study. The treatments involved neutralizing antibodies, standard antiretroviral therapy, and an experimental monoclonal antibody called leronlimab. Co-lead author Dr. Jonah Sacha, a professor at OHSU's National Primate Research Center, expressed excitement over the results.
The study involved numerous collaborators from both Oregon and California primate research centers. While the researchers are unsure why the combination worked so effectively, they believe the therapies become more potent when used together rather than individually. The findings suggest that early intervention after infection may be crucial, with the treatment tested only within 72 hours of initial infection.
Further research is needed to determine the window of effectiveness and whether the approach could eventually benefit adults recently exposed to HIV.
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