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If DNA is the instruction manual, we just opened a big second volume

The findings of a new study imply that genome-wide association studies — an increasingly popular kind of study that looks for the genetic variants linked to diseases — may be missing a significant fraction of heritable variation because that variation is not in the sequence

If DNA is the instruction manual, we just opened a big second volume

A groundbreaking discovery by researchers at Johns Hopkins School of Medicine has unveiled that certain inherited traits in the mouse genome defy the principles set by Gregor Mendel in the 19th century. This revelation is not due to gene mutations, but rather due to chemical modifications in the genome that can be passed down through generations, change based on an animal's sex, and even replicate themselves between gene copies.

These findings, published in Nature Genetics, challenge our understanding of genetics and inheritance patterns. All comments are required to be in English and written as complete sentences, avoiding abusive or personal language.

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