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FMT Shows Promise for Peanut Allergy Tolerance in Phase I Trial

A small Phase I trial found that fecal microbiome transplantation (FMT) increased peanut tolerance in some adults with a peanut allergy, while mouse studies suggested the effect may depend on bile…

  • Phase I trial shows FMT increases peanut reactivity threshold in five participants.
  • Increased tolerogenic regulatory T cells and decreased type 2 helper T cells linked to tolerance.
  • Post-FMT microbiomes protect allergy-prone mice from food allergy.