An in vivo examination of Dynein-Cargo complex formation.

Long-range intracellular transport relies on microtubule motors. This process is particularly important in large cells such as neurons and oocytes. While transport towards the plus-end of microtubules utilizes many kinesins, minus-end transport is largely mediated by a single motor, cytoplasmic dynein. Activation of dynein requires the large dynactin complex as well as a cargo adaptor. How…

biorxiv.org ·2026-08-04

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