Multi-locus pairing expands the functional repertoire of two-peptide bacteriocins
Two-peptide bacteriocins are generally viewed as self-contained systems whose peptides are encoded at the same biosynthetic locus and co-expressed to form an active antimicrobial pair. Here, we show that functional pairing extends beyond this organization. Comparative genomic analysis revealed frequent co-occurrence of putative two-peptide bacteriocins encoded at distinct chromosomal loci in…
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