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Longitudinal miRNA-mRNA Profiling Reveals Network Reorganization in Preeclampsia

Background: Preeclampsia (PE) is a leading cause of maternal and perinatal morbidity. Temporal dynamics of molecular dysregulation across pregnancy remain poorly understood. We performed longitudinal RNA sequencing of maternal whole blood to characterize miRNA-mRNA regulatory network evolution in PE. Methods: Whole-blood samples from early (M1: 10-18 weeks) and late pregnancy (M2: 32-38 weeks)…

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