Key brain area reveals distinct zones whose boundaries blur with age
Scientists in the Center for Human Brain Variation at the Broad Institute have charted previously hidden architecture and patterns of cellular makeup in a key part of the brain called the striatum, which is involved in decision-making and movement and is affected in psychiatric disorders, addiction and neurodegeneration. The findings reveal six new zones within the striatum based on gene…
Scientists at the Broad Institute have mapped the intricate cellular architecture of the striatum, a brain region involved in decision-making and movement. This research revealed six distinct zones within the striatum based on gene expression patterns, with boundaries that blur as individuals age. The study, led by Evan Macosko and Broad Institute member Steve McCarroll, analyzed thousands of cells from postmortem brains to identify these zones and understand how genetic and age-related factors influence gene expression in the brain.
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