DeepRNAi: Predicting on- and off-target siRNA activity and establishing a benchmark
Small interfering RNAs (siRNAs) silence target genes through RISC-mediated hybridization and cleavage, but can silence unintended transcripts and cause toxicity or complicate regulatory approval. In drug development, empirical assessment by qPCR and RNA-seq is slow, forces early candidate prioritization, and is limited by available species- and genome-appropriate cell models. While extensive…
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