Blood NAD levels track heart disease, not aging, study of more than 1,000 adults finds
Vilnius University researchers find that whole-blood NAD levels remain stable with age in healthy men and increase slightly in women, but are lower in people with cardiovascular disease, particularly hypertension.
A study by researchers at Vilnius University in Lithuania has found that whole-blood levels of NAD (nicotinamide adenine dinucleotide), a molecule often linked to aging and longevity, do not decline with age in healthy adults. Instead, these levels remain stable in men and slightly increase in women. The research, published in Nature Metabolism, involved 1,068 adults and suggests that lower NAD levels may be more closely associated with cardiovascular health, particularly hypertension, than with chronological age.
The findings challenge the common belief that NAD declines are an inevitable part of aging and question the effectiveness of NAD-boosting supplements in promoting healthy aging. The study did not find a universal decline in NAD levels among healthy adults and did not establish a cause-and-effect relationship between NAD levels and cardiovascular disease.
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