Amyloidosis and tauopathy progressively disrupt near-critical dynamics in selectively vulnerable circuits
Mechanistically distinct neurodegenerative diseases result in similar cognitive deficits, and pathology is often concentrated in a set of circuits known to be selectively vulnerable. Selective vulnerability is an intrinsic property of a circuit: in APP/PS1 mice, where plaques are global, functional disruptions are confined to circuits within the default mode network. What characterizes the…
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