Algorithms for Designing Therapeutic Oligonucleotides on Pangenome Graphs
Designing therapeutic oligonucleotides that act reliably across human genetic diversity requires more than alignment to a single reference genome. Binding affinity of an siRNA or ASO to a usually complementary site in an mRNA target molecule is one main determinant of drug efficacy. Thus, variation in sub-populations can lead to failures in drug development if this variation reduces binding…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
