Aging exacerbates muscle loss induced by semaglutide treatment in female mice
Background Glucagon-like peptide-1 receptor agonists (GLP-1RAs), including semaglutide, have transformed the pharmacological treatment of obesity. While highly efficacious in promoting weight loss, these drugs also induce substantial reductions in lean mass, raising concerns for skeletal muscle loss, particularly in older individuals vulnerable to sarcopenia. Nevertheless, there are currently no…
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