Versatile and Cross-Species Alveolar Type II Cell Isolation Using Humanized Monoclonal Antibody Upifitamab

Alveolar type 2 (AT2) cells are primary adult alveolar stem cells that maintain healthy alveoli. AT2 cell dysfunction is broadly linked to many lung pathologies from emphysema to fibrosis. Isolation of AT2 cells with high purity is therefore central to diagnostic studies, proteomics, transcriptomics and ex vivo experiments that can lead to future AT2 cellular therapies. Current markers for AT2…

biorxiv.org ·23h ago

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