Lipid-Driven NRF2 Preconditioning Links Estrogen Deprivation to Hepatic Resilience Against Acetaminophen Injury
Background & Aims: Menopause is associated with a sustained decline in estrogen signaling that profoundly alters hepatic lipid metabolism; however, its impact on the liver response to xenobiotic stress remains poorly understood. Given that acetaminophen (APAP) overdose is a leading cause of drug-induced acute liver failure (DILI) and that sex and age influence susceptibility to hepatotoxicity, we…
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