<i>Cis</i>-regulation and natural selection in the evolution of human DNA methylation
The vast collection of human-specific traits—such as our unique morphology, cognition, behavior, and diseases—has long been attributed to gene expression divergence between us and our closest living relatives, chimpanzees. Theory suggests that changes to cis -regulatory elements such as promoters and enhancers may drive evolutionary adaptation, and DNA methylation is a key factor in…
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