Cortical ER-PM contact sites promote nuclear ER membrane integrity and mitotic nuclear segregation
The endoplasmic reticulum (ER) extends from the nuclear envelope through the cytoplasm to the cell cortex, where it contacts the plasma membrane (PM) at ER-PM membrane contact sites (MCSs). We hypothesized that as contiguous extensions of nuclear ER these cortical ER (cER) attachments to the PM might dampen shearing stresses on the nuclear envelope and help orchestrate nuclear ER dynamics.…
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