Zebrafish lack canonical necroptosis despite retaining functional RIPK3
Organismal development, homeostasis and immunity are facilitated by distinct forms of regulated cell death (RCD). These include conserved apoptosis and necroptosis, a proposed backup antimicrobial defence that requires RIPK3-mediated activation of MLKL and is predicted to be absent in several species lacking MLKL. Zebrafish studies have identified a RIPK3-dependent regulated necrosis that is…
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