Within-host evolution of an avirulent Salmonella vaccine strain reveals regulatory tuning of virulence functionality without loss of function
Non-typhoidal Salmonella (NTS) relies on a costly epithelial invasion program encoded in Salmonella pathogenicity island 1 (SPI-1) to overcome microbiota-mediated colonization resistance. Because SPI-1 expression is a cooperative trait in which a minority of invasive SPI-1ON cells benefits the wider bacterial population, inflammatory infection models readily select for permanently avirulent…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
