Saturation barcoding of ribosomal DNA resolves the nucleolar organizer regions of the human genome
The nucleolus is the hub for ribosome biogenesis in eukaryotic cells. It is assembled on nucleolar organizer regions (NORs), tandem arrays of ribosomal DNA (rDNA) units. In humans, each rDNA unit is ~45 kb and encodes the 47S ribosomal RNA (rRNA) precursor. Hundreds of rDNA units are present per germline genome, spread across 10 NORs positioned on the short arms of the five acrocentric…
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