Longitudinal CCR2 PET Imaging Tracks Early Inflammatory Monocyte and Macrophage Infiltration in Experimental Arthritis
Objective. Recruitment of C-C motif chemokine receptor 2 (CCR2+) inflammatory monocytes and macrophages represent an early event in rheumatoid arthritis (RA) pathogenesis that cannot be tracked noninvasively with existing imaging modalities. We evaluated longitudinal Ga-DOTA-ECL1i positron emission tomography/computed tomography (PET/CT) to track and quantify CCR2 cell recruitment in experimental…
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