Investigating the causal and consequential role of the nuclear encoded mitochondrial genome in Amyotrophic Lateral Sclerosis
Mitochondrial dysfunction is implicated in amyotrophic lateral sclerosis (ALS), but which mitochondrial pathways are involved, and whether their involvement is a cause or a consequence of disease remains unclear. We investigated whether nuclear-encoded mitochondrial gene (NEMG) pathways are enriched for ALS genetic risk, which are dysregulated in ALS tissue, whether pathway activity defines…
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