Inferring chromatin looping interactions from microscopy-based measurements: opportunities and pitfalls
Chromatin looping plays essential roles in several nuclear processes and live-cell microscopy has become a key method for studying how chromatin loops behave in time. Extracting dynamical parameters including looping probability, lifetime, and search time from live-imaging data requires inferring looping events from noisy 3D distance trajectories. By analyzing polymer simulation data with known…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
