Hyperglycemia-responsive circRNA drives diabetic neuropathic pain by competing for PUM2 binding and promoting proNT3/CCL2 in DRG neurons
Diabetic neuropathic pain (DNP), one of the most common and debilitating complications of diabetes mellitus (DM), remains poorly managed by conventional analgesics, highlighting the urgent need to explore its etiology-associated mechanisms. Here, we identified a novel conserved circular RNA, cRps6kb1, that is significantly upregulated in dorsal root ganglion (DRG) neurons across multiple mouse…
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