HIV broadly neutralizing antibody precursor maturation induced by mRNA vaccination in nonhuman primates
The induction of broadly neutralizing antibodies (bnAbs) is a principal goal of prophylactic HIV vaccines. For many bnAbs, priming ultrarare precursors from the naive B cell repertoire is the first major immunological hurdle. Previous studies have shown that the germline-targeting (GT) priming immunogen N332-GT5 delivered as adjuvanted protein to non-human primates (NHPs) activates bnAb precursor…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
