High spatiotemporal resolution in vivo imaging reveals preferential PACAP38 action on dural vasculature and a functional therapeutic readout
PACAP38-induced cephalic vasodilation is used to assess functional PACAP pathway inhibition in humans, but the vascular populations underlying this response are not fully resolved. Defining these compartments in a preclinical model could help connect clinical pharmacodynamic responses with the underlying vascular mechanisms and support further development of PACAP-targeted therapies. Using…
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