Differential effects of AMPA receptor inhibition on seizure-like events in murine and human brain slices
Epilepsy is a frequent neurological condition with a worldwide prevalence of 0.5-1%. Current therapies are limited by adverse effects as well as drug resistance. This highlights the need for novel, target-specific antiseizure medications with improved efficacy and fewer side effects. AMPA (-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors represent a therapeutic target as…
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