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A proteomics screen of HIV-1 ASP interactors reveals multifaceted effects on host cell homeostasis

Nearly four decades after the identification of the HIV-1 antisense gene asp, the function of its protein product remains unclear. Evidence of ASP expression in vivo and the high degree of conservation of the asp gene among pandemic HIV-1 strains suggest a beneficial role for the virus. Using a mass spectrometry (MS)-based proteomics screen for ASP interactors, we identified nuclear, cytosolic,…

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