Whole-Brain MRSI Metabolic Connectomics Reveals Network Disruptions and Altered Gradient Coherence in Psychosis Risk

Brain network alterations preceding first-episode psychosis often escape connectomic approaches based on conventional neuroimaging, such as diffusion or functional magnetic resonance imaging (MRI). Whole-brain magnetic resonance spectroscopic imaging (MRSI) offers a potentially more sensitive alternative: by mapping neurometabolites across the brain, it enables the construction of metabolic…

biorxiv.org ·1d ago

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