Unavoidable Disasters: the Hsp70 Chaperone Can Only Prevent Aggregation Over a Limited Time Span
Cells must attain and maintain proper protein folding and avoid aggregation: this is a pervasive challenge across all domains of life. Molecular chaperones are central to this process, acting through mechanisms shaped by the free-energy landscapes of their client proteins. The impact of chaperones on client-specific kinetic and thermodynamic characteristics, however, remains poorly characterized.…
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