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Health & Medicine

Subcellular Spatial Profiling Unveils Links Between Neuritic Plaques with Selective Tau Vulnerability in Alzheimer's Disease

Alzheimer's disease (AD) features widespread extracellular amyloid-{beta} plaques but selective intraneuronal tau accumulation in cortical layers II/III and V, while layer IV remains relatively resistant. Here, we combined subcellular spatial transcriptomics with co-registered A{beta} and pTau immunohistochemistry to determine why neurons exposed to comparable plaque-associated pathology differ…

We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.

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Dengue gallops on

A total of 107,829 dengue cases have been reported across Sri Lanka so far this year, with 81 deaths attributed to the disease, the National Dengue Control Unit (NDCU) said.

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