Spatial proteomics on repurposed sequencers reveals early astrocytic remodeling in an ALS mouse model
Spatial proteomics can reveal how disease reshapes cells and their local environments, but extending these measurements across replicated tissue cohorts requires validated antibodies, consistent sample processing and integrated analysis. These requirements are particularly pressing in studies of amyotrophic lateral sclerosis (ALS), where pathology evolves unevenly across spinal-cord regions and…
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