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Health & Medicine

Preclinical Evaluation of a Novel BOC-Modified Triazoloacridinone (TRA-01AR) in Combination with 5-Fluorouracil in Colorectal Cancer

5-Fluorouracil (5-FU) remains a cornerstone of colorectal cancer (CRC) therapy, yet its clinical efficacy is limited by resistance, systemic toxicity, and unfavorable pharmacokinetics. Strategies that enhance tumor sensitivity while maintaining tolerability are therefore of considerable interest. Here, we evaluated 5-FU in combination with two triazoloacridinones, C-1305 and a novel BOC-modified…

We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.

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Dengue gallops on

A total of 107,829 dengue cases have been reported across Sri Lanka so far this year, with 81 deaths attributed to the disease, the National Dengue Control Unit (NDCU) said.

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