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PhyMorphS: A Physics-Guided Framework for Mesh-Based Morphological Synthesis of White Matter Microstructures

Numerical phantoms provide controlled 3D representations of brain tissue microstructure for developing and evaluating biophysical models of diffusion-weighted Magnetic Resonance Imaging (dMRI). Existing phantom synthesizers employ different geometric primitives and optimization strategies to generate densely packed substrates with diverse axonal morphologies. However, direct deformation of axonal…

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