Parsimonious Creatures: Building Gene Regulatory Networks Robust to Somatic Evolution
For early multicellular life to have formed and maintained cellular organization, preventing loss of controlled cell replication due to somatic evolution was of critical importance, and remains important to this day for control of cancer. We study how gene regulatory networks (GRNs) can be designed to slow the divergence of somatic clonal lineages in the context of early multicellular life. We…
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