One high-order ion-coupling mechanism generates multiple SLC1A stoichiometries
Human excitatory amino acid transporter 2 (hEAAT2) is a glial transporter that clears glutamate and aspartate from the extracellular space to terminate neurotransmission. When this essential role is disrupted, excess extracellular glutamate causes excitotoxicity and neurological disease. hEAAT2 transports amino acids into cells against their concentration gradients by coupling uptake to the…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
