Maternal separation remodels Purkinje cell circuits and impairs cerebellar synaptic plasticity
Introduction: Early-life adversity has been associated with cerebellar abnormalities, but the cellular and circuit-level changes involved and their persistence across development remain poorly understood. We examined whether maternal separation (MS) disrupts cerebellar circuit maturation and whether these changes are accompanied by alterations in synaptic function and behavior. Methods: CD1 mice…
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