KLONE: An Imbalance-Robust k-NN Ensemble for Cross-Modal Single-Cell Clone Assignment
Single-cell DNA sequencing (scDNA-seq) and single-cell RNA sequencing (scRNA-seq) enable the inference of copy number clones and transcriptional states in tumor studies. However, these two assays usually profile different cells of the same tumor, requiring computational assignment of unpaired scRNA-seq cells to clones identified by scDNA-seq to link clonal genotypes with transcriptional profiles.…
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