IL13 critically contributes to the antitumor activity of polyfunctional CD4+ T cells driven by constitutively active Stat5
The presence of polyfunctional T cells capable of concurrently producing multiple cytokines correlates with favorable clinical outcomes in patients with cancer. We previously reported that overexpression of constitutively active Stat5a (CASTAT5) confers polyfunctionality on tumor-specific CD4 T cells, enabling durable antitumor immunity following adoptive cell therapy. However, the mechanisms…
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